Ikhithi Yesikhathi Se-Thromboplastin Engaphelele Esebenzayo (i-APTT)

Ukulinganisa i-APTT kuyindlela yokuhlola esetshenziswa kakhulu emtholampilo ukuze kuboniswe umsebenzi wokujiya kwesistimu yokujiya kwe-endogenous. Isetshenziselwa ukuthola amaphutha e-endogenous coagulation factor kanye nezithiyo ezihlobene nokuhlola isimo sokumelana kwe-protein C esebenzayo. Inezindlela eziningi zokusebenzisa maqondana nokuhlola, ukuqapha ukwelashwa kwe-heparin, ukuxilongwa kwangaphambi kwesikhathi kwe-disseminated intravascular coagulation (DIC), kanye nokuhlolwa kwangaphambi kokuhlinzwa.

Ukubaluleka komtholampilo:

I-APTT iyinkomba yokuhlola umsebenzi wokujiya ekhombisa indlela yokujiya kwe-endogenous, ikakhulukazi umsebenzi ophelele wezinto ezijiya esigabeni sokuqala. Isetshenziswa kabanzi ukuhlola nokunquma amaphutha ezici ezijiya endleleni ye-endogenous, njenge-factor Ⅺ, Ⅷ, Ⅸ, ingasetshenziswa futhi ekuhlolweni kokuqala kwezifo zokopha kanye nokuqapha kwelabhorethri ukwelashwa kwe-heparin anticoagulation.

1. Isikhathi eside: kungabonakala ku-hemophilia A, i-hemophilia B, isifo sesibindi, isifo sokubulala amathumbu, ama-anticoagulants omlomo, ukujiya kwemithambo yegazi esakazekile, i-hemophilia encane; ukuntuleka kwe-FXI, i-FXII; igazi Izinto ezivimbela ukujiya kwegazi (izithibi ze-coagulation factor, ama-lupus anticoagulants, i-warfarin noma i-heparin) zanda; inani elikhulu legazi eligciniwe lafakwa.

2. Ukufinyeza: Kungabonakala esimweni sokujiya kwegazi ngokweqile, izifo ze-thromboembolic, njll.

Ububanzi bereferensi yenani elijwayelekile

Inani elijwayelekile lereferensi lesikhathi se-activated partial thromboplastin (APTT): imizuzwana engu-27-45.

Izinyathelo zokuzivikela

1. Gwema i-hemolysis yesampula. Isampula efakwe i-hemolyzed iqukethe ama-phospholipid akhishwa ukuqhekeka kwe-membrane yamaseli abomvu egazi avuthiwe, okwenza i-APTT ibe ngaphansi kunenani elilinganisiwe lesampula engeyona i-hemolyzed.

2. Iziguli akufanele zenze imisebenzi enzima zingakapheli imizuzu engama-30 ngaphambi kokuthatha isampula yegazi.

3. Ngemva kokuqoqa isampula yegazi, shukumisa kancane ithubhu yokuhlola equkethe isampula yegazi izikhathi ezintathu kuya kwezi-5 ukuze uhlanganise ngokuphelele isampula yegazi ne-anticoagulant ethubhu yokuhlola.

4. Amasampula egazi kufanele athunyelwe ukuze ayohlolwa ngokushesha okukhulu.