Ukwakheka kwe-thrombus kunxulumene nokulimala kwemithambo yegazi, ukujiya kwegazi kakhulu, kunye nokuhamba kwegazi okucothayo. Ke ngoko, abantu abanezi zinto zintathu zinobungozi basengozini ye-thrombus.

1. Abantu abanobungozi be-endothelial yemithambo yegazi, njengabo baye babhajwa ngemithambo yegazi, bafakwa i-catheterization yemithambo yegazi, njl.njl., ngenxa ye-endothelium yemithambo yegazi eyonakeleyo, ii-collagen fibers ezivezwe phantsi kwe-endothelium zinokuvuselela iiplatelets kunye nezinto ezibangela ukujiya kwegazi, ezinokubangela ukujiya kwegazi emzimbeni. Le nkqubo ibangela i-thrombosis.

2. Abantu abanegazi elikwimeko yokungakwazi ukujiya igazi, njengabaguli abaneethumba ezinobungozi, i-systemic lupus erythematosus, ukwenzakala okukhulu okanye utyando olukhulu, banezinto ezininzi zokujiya igazi kwaye banamathuba amaninzi okujiya igazi kunegazi eliqhelekileyo, ngoko ke banamathuba amaninzi okwenza i-thrombosis. Omnye umzekelo ngabantu abathatha izithintelo zokukhulelwa, i-estrogen, i-progesterone kunye nezinye iziyobisi ixesha elide, umsebenzi wabo wokujiya igazi uya kuchaphazela, kwaye kulula ukwenza amahlwili egazi.

3. Abantu abahamba ngegazi kancinci, njengabo bahlala phantsi ixesha elide bedlala i-mahjong, bebukela iTV, befunda, bethatha iklasi yezoqoqosho, okanye behlala ebhedini ixesha elide, ukungabikho komsebenzi womzimba kunokubangela ukuba ukuhamba kwegazi kunciphe okanye kume. Ukwakheka kwee-vortices kutshabalalisa imeko eqhelekileyo yokuhamba kwegazi, nto leyo eya kwandisa amathuba okuba iiplatelets, ii-endothelial cells kunye nezinto ezibangela ukuxinana kwegazi ziqhagamshelane, kwaye kulula ukwenza i-thrombus.