Inkqubo ye-Thrombosis, equka iinkqubo ezi-2:

1. Ukunamathela kunye nokuhlanganiswa kweeplatelets egazini

Kwinqanaba lokuqala le-thrombosis, iiplatelets zihlala ziphuma kwi-axial flow kwaye zinamathele kumphezulu weefayibha ze-collagen eziveziweyo kwi-intima yemithambo yegazi eyonakeleyo. Iiplatelets zivuselelwa yi-collagen kwaye zikhupha izinto ezifana ne-ADP, i-thromboxane A2, i-5-AT kunye ne-platelet factor IV. Ezi zinto zinefuthe elinamandla lokudityaniswa kweeplatelets, ukuze iiplatelets egazini ziqhubeke nokudityaniswa kwindawo ethile ukuze zenze inqwaba yeeplatelets ezimile okwe-mound. , ukuqala kwe-venous thrombosis, intloko ye-thrombus.

Iiplatelets zinamathela kumphezulu weefayibha ze-collagen eziveziweyo kwi-intima yomthambo wegazi owonakeleyo kwaye ziyasebenza ukuze zenze i-platelet stack efana ne-hillock. I-hillock iyanda kancinci kancinci kwaye ixubana nee-leukocytes ukuze zenze i-white thrombus. Inee-leukocytes ezininzi ezinamathele kumphezulu wayo. Ukuhamba kwegazi kuyancipha kancinci kancinci, inkqubo yokuxinana iyasebenza, kwaye inani elikhulu le-fibrin lenza isakhiwo senethiwekhi, esibamba iiseli ezibomvu zegazi ezininzi kunye neeseli ezimhlophe zegazi ukuze zenze i-mixed thrombus.

2. Ukujiya kwegazi

Emva kokuba i-thrombus emhlophe yenziwe, iphuma iye kwi-lumen yemithambo yegazi, ibangela ukuba ukuhamba kwegazi emva kwayo kunciphe kwaye kubonakale ngathi yi-whirlpool, kwaye kwenziwa i-platelet mound entsha kwi-whirlpool. Ii-Trabeculae, ezimile njenge-coral, zine-leukocytes ezininzi ezinamathele kumphezulu wazo.

Ukuhamba kwegazi phakathi kwe-trabeculae kuyacotha kancinci kancinci, inkqubo yokuxinana kwegazi iyasebenza, kwaye uxinzelelo lwezinto zokuxinana kwegazi zasekuhlaleni kunye nezinto ze-platelet ziyanda kancinci kancinci, zenze kwaye zihlangane zibe yisakhiwo se-mesh phakathi kwe-trabeculae. I-thrombus emhlophe nemhlophe, exutyiweyo, eyenza umzimba we-thrombus.

I-thrombus exutyiweyo yanda kancinci kancinci yaza yanda kwicala lokuhamba kwegazi, yaza ekugqibeleni yavala ngokupheleleyo i-lumen yemithambo yegazi, nto leyo eyabangela ukuba ukuhamba kwegazi kume.