Xa umsebenzi ongemhle wesigulane wokujiya kwegazi ukhokelela ekopheni, oku kunokubangelwa kukuncipha komsebenzi wokujiya kwegazi. Uvavanyo lwezinto ezijiya igazi luyafuneka. Kuyacaca ukuba ukopha kwegazi kubangelwa kukungabikho kwezinto ezijiya igazi okanye ezinye izinto ezichasene nokujiya kwegazi. Ngokwesizathu, yongeza izinto ezijiya igazi okanye iplasma entsha. Ukubakho kwezinto ezijiya igazi ezininzi kunokunceda ekumiseni ukopha kwegazi. Ngokwezonyango, kunokufunyaniswa ukuba izinto ezijiya igazi ezihambelanayo zeendlela zangaphakathi nezangaphandle zokujiya kwegazi zinciphile okanye azinawo ukungasebenzi kakuhle, kwaye ujonge ukuba umsebenzi wokujiya igazi ongaqhelekanga ubangelwa kukungabikho kwezinto ezijiya igazi okanye umsebenzi wezinto ezijiya igazi, ikakhulu kuquka ezi meko zilandelayo:

1. Indlela engaqhelekanga yokujiya kwe-endogenous: Eyona nto iphambili yokujiya kwe-endogenous coagulation factor echaphazela indlela yokujiya kwe-endogenous yi-APTT. Ukuba i-APTT ithatha ixesha elide, oko kuthetha ukuba kukho izinto ezingaqhelekanga zokujiya kwe-endogenous pathway, ezifana ne-factor 12, i-factor 9, i-factor 8, kunye ne-common pathway 10. Ukungabikho kwe-factor kunokubangela iimpawu zokopha kwizigulana;

2. Indlela engaqhelekanga yokujiya kwe-extrinsic: ukuba i-PT ithatha ixesha elide, kunokufunyaniswa ukuba i-tissue factor, i-factor 5 kunye ne-factor 10 kwindlela eqhelekileyo zonke zisenokuba aziqhelekanga, oko kukuthi, ukwehla kwenani kukhokelela kwixesha elide lokujiya kwe-coagulation kwaye kubangele ukopha kwisigulana.