Umzimba oqhelekileyo unenkqubo epheleleyo yokujiya kunye neyokuthintela ukujiya kwegazi. Inkqubo yokujiya kunye nenkqubo yokuthinteya ukujiya kwegazi zigcina ibhalansi eguquguqukayo ukuqinisekisa ukuba i-hemostasis yomzimba kunye nokuhamba kwegazi okutyibilikayo. Nje ukuba ibhalansi yomsebenzi wokujiya kunye nokuthintela ukujiya kwegazi iphazamisekile, kuya kukhokelela ekubeni igazi lijiye kwaye liqalise ukurhawuzelelwa yi-thrombosis.

1. Umsebenzi womzimba wokujiya

Inkqubo yokujiya kwe-coagulation yenziwe ikakhulu zizinto ezijiyayo. Izinto ezibandakanyeka ngokuthe ngqo ekujiya kwe-coagulation zibizwa ngokuba zizinto ezijiyayo. Kukho izinto ezili-13 ezijiyayo eziqatshelwayo.

Kukho iindlela zokuvuselela ezisuka emzimbeni ukuya emzimbeni kunye neendlela zokuvuselela eziphuma ngaphandle ukuze kusebenze izinto ezibangela ukujiya kwegazi.

Okwangoku kukholelwa ukuba ukusebenza kwenkqubo yokujiya kwangaphandle okuqalwa yi-tissue factor kudlala indima enkulu ekuqaliseni ukujiya. Unxibelelwano olusondeleyo phakathi kweenkqubo zokujiya kwangaphakathi nangaphandle ludlala indima ebalulekileyo ekuqaliseni nasekugcineni inkqubo yokujiya.

2. Umsebenzi womzimba wokuthintela ukugabha kwegazi

Inkqubo yokuthintela ukujiya kwegazi ibandakanya inkqubo yokuthintela ukujiya kwegazi kwiiseli kunye nenkqubo yokuthintela ukujiya kwegazi emzimbeni.

①Inkqubo yokuthintela ukujiya kweeseli

Ibhekisa kwi-phagocytosis ye-coagulation factor, i-tissue factor, i-prothrombin complex kunye ne-soluble fibrin monomer yi-mononuclear-phagocyte system.

②Inkqubo yokuthintela ukujiya kwegazi emzimbeni

Kubandakanya: ii-serine protease inhibitors, ii-protein C-based protease inhibitors kunye nee-tissue factor pathway inhibitors (TFPI).

3. Inkqubo ye-Fibrinolytic kunye nemisebenzi yayo

Ikakhulu ziquka i-plasminogen, i-plasmin, i-plasminogen activator kunye ne-fibrinolysis inhibitor.

Indima yenkqubo ye-fibrinolytic: inyibilikisa amahlwili e-fibrin kwaye iqinisekise ukujikeleza kwegazi okuhamba kakuhle; ithatha inxaxheba ekulungisweni kwezicubu kunye nokuvuselelwa kwemithambo yegazi.

4. Indima yeeseli ze-endothelial zemithambo-luvo kwinkqubo yokujiya, ukuthintela ukujiya kwegazi kunye ne-fibrinolysis

① Velisa izinto ezahlukeneyo ezisebenzayo kwibhayoloji;

②Lawula ukujiya kwegazi kunye nomsebenzi wokuthintela ukujiya kwegazi;

③Lungisa umsebenzi wenkqubo ye-fibrinolysis;

④ Lawula uxinzelelo lwemithambo yegazi;

⑤Thatha inxaxheba ekulungiseni ukudumba;

⑥ Gcina umsebenzi we-microcirculation, njl.

Izifo zokuxinana kwegazi kunye ne-anticoagulant

1. Ukungaqheleki kwezinto ezibangela ukujiya kwegazi.

2. Ukungaqheleki kwezinto ezithintela ukopha kwegazi kwi-plasma.

3. Ukungaqheleki kwe-fibrinolytic factor kwi-plasma.

4. Ukungaqheleki kweeseli zegazi.

5. Imithambo yegazi engaqhelekanga.