Ikhithi yeXesha leThromboplastin eSebenzisiweyo (i-APTT)

Uvavanyo lwe-APTT lolona lusetyenziswa kakhulu kuvavanyo lokuhlola olusenyongweni lweklinikhi ukubonisa umsebenzi wokujiya kwe-endogenous coagulation system. Lusetyenziselwa ukufumanisa iziphene ze-endogenous coagulation factor kunye nezithinteli ezinxulumene noko kunye nokuhlola imeko yokuxhathisa kwe-protein C esebenzayo. Luneendlela ezahlukeneyo zokusetyenziswa ngokubhekiselele ekuhlolweni, esweni unyango lwe-heparin, ekuxilongweni kwangethuba kwe-distributed intravascular coagulation (DIC), kunye novavanyo lwangaphambi kotyando.

Ukubaluleka kweklinikhi:

I-APTT luvavanyo lomsebenzi wokujiya olubonisa indlela yokujiya kwe-endogenous, ingakumbi umsebenzi opheleleyo wezinto ezijiya kwisigaba sokuqala. Isetyenziswa kakhulu ukuhluza nokuchonga iziphene zezinto ezijiya kwi-endogenous pathway, ezifana ne-factor Ⅺ, Ⅷ, Ⅸ, ingasetyenziselwa ukuhluza izifo zokopha kwangaphambi kwexesha kunye nokubeka esweni ilabhoratri yonyango lwe-heparin anticoagulation.

1. Ixesha elide: linokubonwa kwi-hemophilia A, i-hemophilia B, isifo sesibindi, isifo sokubulala amathumbu, ii-anticoagulants zomlomo, i-diffuse intravascular coagulation, i-hemophilia encinci; i-FXI, i-FXII deficiency; igazi Izinto ezithintela i-coagulant (izithinteli ze-coagulation factor, ii-lupus anticoagulants, i-warfarin okanye i-heparin) zanda; inani elikhulu legazi eligciniweyo latofelwa.

2. Ukufinyeza: Ingabonakala kwimeko yokuxinana kwegazi, izifo ze-thromboembolic, njl.njl.

Uluhlu lwesalathiso sexabiso eliqhelekileyo

Ixabiso eliqhelekileyo lereferensi yexesha elisebenzayo le-thromboplastin engaphelelanga (APTT): imizuzwana engama-27-45.

Ukulumkela

1. Kuphephe ukubola kwe-sampuli. Isampuli efakwe i-hemolyzed inee-phospholipids ezikhutshwa kukuqhekeka kwe-membrane yeseli ebomvu yegazi evuthiweyo, nto leyo eyenza i-APTT ibe phantsi kunexabiso elilinganisiweyo lesampuli engeyiyo efakwe i-hemolyzed.

2. Izigulana akufuneki zenze imisebenzi enzima kwimizuzu engama-30 ngaphambi kokuba zithole isampuli yegazi.

3. Emva kokuqokelela isampuli yegazi, shukumisa kancinci ityhubhu yovavanyo equlethe isampuli yegazi izihlandlo ezi-3 ukuya kwezi-5 ukuze udibanise ngokupheleleyo isampuli yegazi ne-anticoagulant ekwityhubhu yovavanyo.

4. Iisampuli zegazi mazithunyelwe ukuze zihlolwe ngokukhawuleza.