FIB ndi chidule cha Chingerezi cha fibrinogen, ndipo fibrinogen ndi chinthu cholimbitsa magazi. Kuchuluka kwa magazi oundana (FIB value) kumatanthauza kuti magazi ali mu mkhalidwe wokhuthala kwambiri, ndipo magazi otuluka m'magazi amapangika mosavuta.

Pambuyo poti njira yolumikizirana ya munthu yayamba kugwira ntchito, fibrinogen imakhala fibrin monomer pansi pa mphamvu ya thrombin, ndipo fibrin monomer imatha kusonkhana kukhala fibrin polymer, yomwe imathandiza kupanga magazi kuundana ndipo imagwira ntchito yofunika kwambiri pakupanga magazi kuundana.

Fibrinogen imapangidwa makamaka ndi ma hepatocytes ndipo ndi puloteni yokhala ndi ntchito yotseka. Mtengo wake wabwinobwino ndi pakati pa 2 ~ 4qL. Fibrinogen ndi chinthu chogwirizana ndi kutseka kwa magazi, ndipo kuwonjezeka kwake nthawi zambiri kumakhala chifukwa cha zochita zinazake za thupi ndipo ndi chinthu chomwe chimayambitsa matenda okhudzana ndi kutsekeka kwa magazi m'thupi.
Kugayika kwa magazi m'thupi (COAGUMENT) kungawonjezereke m'matenda ambiri, monga majini kapena kutupa, mafuta ambiri m'magazi, komanso kuthamanga kwa magazi.

Matenda a mtima okwera, matenda a shuga, chifuwa chachikulu, matenda olumikizana ndi minofu, matenda a mtima, ndi zotupa zoyipa. Munthu akamadwala matenda onsewa angayambitse magazi kuundana. Chifukwa chake, magazi kuundana kwambiri FIB value imatanthauza mkhalidwe wa magazi kuundana kwambiri.