Njira ya thrombosis, kuphatikizapo njira ziwiri:

1. Kumatira ndi kusonkhanitsa ma platelet m'magazi

Poyamba matenda a thrombosis, ma platelet amatuluka nthawi zonse kuchokera ku axial flow ndipo amamatira pamwamba pa ulusi wa collagen womwe umawonekera pafupi ndi mitsempha yamagazi yowonongeka. Ma platelet amayatsidwa ndi collagen ndipo amatulutsa zinthu monga ADP, thromboxane A2, 5-AT ndi platelet factor IV. Zinthuzi zimakhala ndi mphamvu yayikulu yosonkhanitsa ma platelet, kotero kuti ma platelet m'magazi amapitiliza kusonkhana pamalopo kuti apange mulu wa ma platelet wooneka ngati mulu. , chiyambi cha venous thrombosis, mutu wa thrombus.

Ma platelet amamatira pamwamba pa ulusi wa collagen womwe umawonekera pafupi ndi mtsempha wamagazi wowonongeka ndipo amayatsidwa kuti apange gulu la ma platelet lofanana ndi hillock. Hillock pang'onopang'ono imawonjezeka ndipo imasakanikirana ndi ma leukocyte kuti ipange thrombus yoyera. Ili ndi ma leukocyte ambiri olumikizidwa pamwamba pake. Kuyenda kwa magazi kumachepa pang'onopang'ono, njira yolumikizirana imayatsidwa, ndipo kuchuluka kwa fibrin kumapanga kapangidwe ka netiweki, komwe kamasunga maselo ofiira ambiri ndi maselo oyera kuti apange thrombus yosakanikirana.

2. Kugayika kwa magazi

Pambuyo poti magazi oyera apangidwa, amatuluka mu lumen ya mitsempha yamagazi, zomwe zimapangitsa kuti magazi ayende pang'onopang'ono kumbuyo kwake ndikuwoneka ngati whirlpool, ndipo platelet mound yatsopano imapangidwa pa whirlpool. Ma Trabeculae, opangidwa ngati coral, ali ndi ma leukocyte ambiri omangiriridwa pamwamba pawo.

Kuyenda kwa magazi pakati pa trabeculae kumachepa pang'onopang'ono, njira yolumikizirana imayatsidwa, ndipo kuchuluka kwa zinthu zolumikizirana m'deralo ndi zinthu zolumikizirana m'maselo kumawonjezeka pang'onopang'ono, zomwe zimapangitsa ndikulumikizana kukhala kapangidwe ka mesh pakati pa trabeculae. Thrombus yoyera ndi yoyera, yosakanikirana yomwe imapanga thupi la thrombus.

Thrombosis yosakanikirana pang'onopang'ono inawonjezeka ndikukula motsatira njira yoyendera magazi, ndipo pamapeto pake inatseka kwathunthu lumen ya mitsempha yamagazi, zomwe zinapangitsa kuti magazi asiye kuyenda.