Thupi labwinobwino limakhala ndi njira yonse yolumikizira magazi ndi yoletsa magazi kuundana. Njira yolumikizira magazi ndi njira yoletsa magazi kuundana zimakhala ndi mphamvu yosinthasintha kuti magazi aziyenda bwino m'thupi komanso kuti magazi aziyenda bwino. Njira yolumikizira magazi ndi yoletsa magazi kuundana ikasokonekera, izi zimapangitsa kuti magazi azituluka komanso kuti magazi azituluka magazi ambiri.

1. Ntchito ya thupi yolimbitsa thupi

Dongosolo logaya magazi limapangidwa makamaka ndi zinthu zogaya magazi. Zinthu zomwe zimakhudzidwa mwachindunji ndi kugaya magazi zimatchedwa zinthu zogaya magazi. Pali zinthu 13 zodziwika bwino zogaya magazi.

Pali njira zoyambitsa matenda a endogenous ndi njira zoyambitsa matenda a exogenous kuti ayambe kutsekereza zinthu zotsekereza magazi.

Pakadali pano akukhulupirira kuti kuyambitsa kwa dongosolo lakunja lolumikizirana lomwe limayambitsidwa ndi chinthu cha minofu kumachita gawo lalikulu pakuyambitsa kugawanika kwa magazi. Kugwirizana kwapafupi pakati pa machitidwe amkati ndi akunja olumikizirana magazi kumachita gawo lofunikira pakuyambitsa ndikusunga njira yolumikizirana.

2. Ntchito ya thupi yoletsa magazi kuundana

Dongosolo loletsa magazi kuundana limaphatikizapo dongosolo loletsa magazi kuundana m'maselo ndi dongosolo loletsa magazi kuundana m'thupi.

①Maselo oletsa magazi kuundana

Amatanthauza phagocytosis ya coagulation factor, tissue factor, prothrombin complex ndi soluble fibrin monomer ndi mononuclear-phagocyte system.

②Madzimadzi amthupi oletsa magazi kuundana

Kuphatikizapo: zoletsa za serine protease, zoletsa za protease zochokera ku protein C ndi zoletsa za tissue factor pathway (TFPI).

3. Dongosolo la Fibrinolytic ndi ntchito zake

Makamaka amaphatikizapo plasminogen, plasmin, plasminogen activator ndi fibrinolysis inhibitor.

Ntchito ya dongosolo la fibrinolytic: kusungunula ma fibrin clots ndikuwonetsetsa kuti magazi akuyenda bwino; kutenga nawo mbali pakukonzanso minofu ndi kukonzanso mitsempha yamagazi.

4. Udindo wa maselo a endothelial a mitsempha yamagazi pakupanga magazi oundana, oletsa magazi kuundana ndi fibrinolysis

① Kupanga zinthu zosiyanasiyana zomwe zimagwira ntchito m'thupi;

②Kuwongolera kuuma kwa magazi ndi ntchito yoletsa kuuma kwa magazi;

③ Sinthani ntchito ya dongosolo la fibrinolysis;

④ Kuwongolera kupsinjika kwa mitsempha yamagazi;

⑤Tengani nawo mbali pothandiza kutupa;

⑥Kusunga ntchito ya microcirculation, ndi zina zotero.

Matenda a magazi otsekeka ndi anticoagulant

1. Zolakwika pa zinthu zotsekeka kwa magazi.

2. Kusakhazikika kwa zinthu zoletsa magazi kulowa m'magazi mu plasma.

3. Kusakhazikika kwa fibrinolytic factor mu plasma.

4. Kusakhazikika kwa maselo a magazi.

5. Mitsempha yamagazi yosakhazikika.