What are the types of hemorrhagic diseases that can be classified into?

Author: Succeeder    

There are various types of hemorrhagic diseases, which are mainly classified clinically based on their etiology and pathogenesis. It can be divided into vascular, platelet, coagulation factor abnormalities, etc.
(1) Hereditary: hereditary telangiectasia, vascular hemophilia, and abnormal supporting tissue around blood vessels;
(2) Acquired: vascular wall damage caused by allergic purpura, simple purpura, drug-induced purpura, age-related purpura, autoimmune purpura, infection, metabolic factors, chemical factors, mechanical factors, etc.

2. Platelet properties:
(1) Thrombocytopenia: immune thrombocytopenia, drug-induced thrombocytopenia, aplastic anemia, tumor infiltration, leukemia, immune diseases, DIC, splenic hyperfunction, thrombotic thrombocytopenic purpura, etc;
(2) Thrombocytosis: Primary thrombocytosis, true polycythemia, splenectomy, swelling, inflammatory platelet dysfunction, thrombocytopenia, giant platelet syndrome, liver disease, and platelet dysfunction caused by uremia.

3. Abnormal coagulation factors:
(1 )Hereditary coagulation factor abnormalities: hemophilia A, hemophilia B, FXI, FV, FXI, FVII, FVIII, deficiency, congenital low (absent) fibrinogen, prothrombin deficiency, and complex coagulation factor deficiency;
(2) Acquired coagulation factor abnormalities: liver disease, vitamin K deficiency, acute leukemia, lymphoma, connective tissue disease, etc.

(1) Primary: Hereditary deficiency of fibrinolytic inhibitors or increased plasminogen activity can easily induce hyperfibrinolysis in severe liver diseases, tumors, surgeries, and trauma;
(2) Acquired: visible in thrombosis, DIC, and severe liver disease (secondary)

Pathological increase in circulating substances, acquired inhibitors such as F VIII, FX, F XI, and F XII, autoimmune diseases, malignant tumors, increased levels of heparin like anticoagulants, and lupus anticoagulants.

Reference: [1] Xia Wei, Chen Tingmei. Clinical Hematology Testing Techniques. 6th Edition [M]. Beijing. People's Health Publishing House. 2015

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