Ko te TT e pā ana ki te wā toto totoka i muri i te tāpiri i te thrombin paerewa ki te plasma. I roto i te ara totoka noa, ka hurihia e te thrombin i hangaia te fibrinogen hei fibrin, ka taea te whakaata e te TT. Nā te mea ka taea e ngā hua pirau fibrin (proto) (FDP) te whakaroa i te TT, ka whakamahia e ētahi tāngata te TT hei whakamātautau tirotiro mō te pūnaha fibrinolytic.
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