Ko te rerekētanga matua i waenga i te whakapūpū toto me te whakapūpū toto, ko te whakapūpū toto e pā ana ki te whakakotahitanga o ngā toto whero me ngā pereti toto i roto i te toto hei aukati i raro i te whakaohooho o waho, ko te whakapūpū toto ia e pā ana ki te hanganga o tētahi whatunga whakapūpū e ngā mea whakapūpū toto i roto i te toto mā roto i tētahi raupapa o ngā tauhohenga whākōkī.

1. He tukanga tere, he tukanga hoki te whakakotahitanga o te toto, e hangaia ana e te whakakotahitanga o ngā toto whero me ngā pereti toto, e puta ana i raro i ngā whakaohooho pēnei i te whara, te mumura rānei. He tukanga puhoi, he tukanga kore hoki e taea te whakakore te whakakotahitanga o te toto, e hanga ana i tētahi whatunga whakakotahitanga mā roto i tētahi raupapa o ngā tauhohenga thrombin matatini, e puta ana i te wā e whara ana ngā oko toto.

2. Ko te kaupapa matua o te whakakotahitanga toto he hanga i ngā toto toto hei ārai i te toto. Ko te kaupapa matua o te whakakotahitanga toto he hanga i ngā toto toto ki te wāhi i whara ai ngā uaua toto, te whakatika i ngā uaua toto, me te whakamutu i te toto.

3. Ko te whakapūnga toto e pā ana ki te kohikohinga o ngā toto whero me ngā pereti toto, ko te whakapūnga toto e pā ana ki te whakahohe me te kohikohinga o ngā mea whakapūnga toto, ngā whākōkī, me te fibrinogen i roto i te toto.

4. I te wā e kohikohi ana te toto, he tino wetekina te thrombus i hangaia e te kohikohinga o ngā toto toto whero me ngā pereti toto, ā, he ngāwari ki te pakaru. I te wā e kohikohi ana te toto, he tino pumau ngā putunga fibrin i hangaia, ā, he uaua ki te pakaru.

5. Ko te toto totoka ka puta i te wāhi i whara ai, i mumura ai rānei, ko te toto totoka ia ka puta i roto i ngā oko toto, inā koa i ngā pakitara o ngā oko toto kua pakaru.

Me mārama ko te kohikohinga toto me te whakapūnga toto he tukanga ā-tinana e rua e pā ana engari he rerekē. Ko te mate o te whakapūnga toto me te whakapūnga toto ka arahi pea ki ngā mate pēnei i te toto, te thrombosis rānei, nō reira he mea nui te ako i ōna tikanga haumanu.