A na-ahụkarị thrombosis site na mmebi nke mkpụrụ ndụ endothelial obi, ọnọdụ ọbara na-adịghị mma, na mmụba nke coagulation ọbara.

1. Mmerụ ahụ nke mkpụrụ ndụ obi na akwara: Mmerụ ahụ nke mkpụrụ ndụ akwara bụ ihe kachasị mkpa na ihe na-akpata mmepe nke thrombus, nke a na-ahụkarị na rheumatic na endocarditis nke na-efe efe, ọnya plaque atherosclerotic dị njọ, mmerụ ahụ ma ọ bụ mmegharị mkpali ebe mmerụ ahụ venous, wdg. Na mgbakwunye, mgbe hypoxia, ujo, sepsis na nje bacteria endotoxin na-akpata nnukwu mmebi endothelial n'ahụ niile, collagen dị n'okpuru endothelium na-eme ka usoro coagulation rụọ ọrụ, na-ebute coagulation intravascular gbasaa, na thrombus na-etolite na microcirculation nke ahụ dum.

2. Ọnọdụ ọbara na-adịghị mma: nke bụ isi na-ezo aka na mbelata ọbara na mmepụta nke eddies na ọbara, wdg. Ihe ndị na-eme ka coagulation na thrombin rụọ ọrụ na-eru oke achọrọ maka coagulation na mpaghara ahụ, nke na-enyere aka ịmepụta thrombus. N'ime ha, akwara na-enwekarị thrombus, nke a na-ahụkarị na ndị ọrịa nwere nkụda obi, ọrịa na-adịghị ala ala na ezumike akwa mgbe a wachara ahụ. Na mgbakwunye, ọbara na-eru ngwa ngwa n'obi na akwara na-adị ngwa ngwa, ọ dịghịkwa mfe ịmepụta thrombus. Agbanyeghị, mgbe ọbara na-erugharị na atrium aka ekpe, aneurysm, ma ọ bụ alaka nke arịa ọbara na-adị nwayọ ma eddy current na-eme n'oge mitral valve stenosis, ọ na-enwekwa thrombosis.

3. Mmụba nke ọbara coagulation: N'ozuzu, mmụba nke platelet na ihe ndị na-akpata coagulation n'ọbara, ma ọ bụ mbelata na ọrụ nke sistemụ fibrinolytic, na-eduga na ọnọdụ coagulation dị elu n'ọbara, nke a na-ahụkarị na steeti eketa na nke enwetara hypercoagulation.

Tinyere nke ahụ, ọbara akwara adịghị mma nwekwara ike ibute ya. Dịka nchọpụta dị irè nke ọrịa nke onwe onye si dị, enwere ike imezu mgbochi sayensị na ọgwụgwọ ezubere iche iji nyere aka gbakee ahụike.