A na-ejikarị D-dimer eme ihe dị ka otu n'ime ihe ndị a na-enyo enyo na ha na-egosi PTE na DVT n'ọrụ ahụike. Olee otú o si malite?

Plasma D-dimer bụ ngwaahịa mmebi kpọmkwem nke plasmin hydrolysis mepụtara mgbe ejiri fibrin monomer jikọta ya site na ime ka ihe XIII rụọ ọrụ. Ọ bụ ihe nrịbama kpọmkwem nke usoro fibrinolysis. A na-enweta D-dimers site na mkpọchi fibrin cross-linked nke plasmin lysed. Ọ bụrụhaala na enwere thrombosis na ọrụ fibrinolytic na arịa ọbara nke ahụ, D-dimer ga-abawanye. Myocardial infarction, cerebral infarction, pulmonary embolism, venous thrombosis, ịwa ahụ, tumor, mgbasa ọbara intravascular, ọrịa na necrosis anụ ahụ nwere ike ibute mmụba D-dimer. Karịsịa maka ndị agadi na ndị ọrịa nọ n'ụlọ ọgwụ, n'ihi nje bacteria na ọrịa ndị ọzọ, ọ dị mfe ibute coagulation ọbara na-adịghị mma ma na-eduga na mmụba D-dimer.

D-dimer na-egosipụtakarị ọrụ fibrinolytic. A na-ahụ mmụba ma ọ bụ dị mma na hyperfibrinolysis nke abụọ, dịka ọnọdụ hypercoagulable, mgbasa nke coagulation intravascular, ọrịa akụrụ, ịjụ transplant akụkụ ahụ, ọgwụgwọ thrombolytic, wdg. Nchọpụta nke isi ihe ndị dị na sistemụ fibrinolytic dị oke mkpa maka nchọpụta na ọgwụgwọ nke ọrịa nke sistemụ fibrinolytic (dịka DIC, thrombus dị iche iche) na ọrịa ndị metụtara sistemụ fibrinolytic (dịka etuto ahụ, ọrịa ime ime), na nlekota nke ọgwụgwọ thrombolytic.

Mmụba nke D-dimer, nke bụ ngwaahịa mbibi fibrin, na-egosi mmebi fibrin ugboro ugboro na vivo. Ya mere, fibrous D-dimer bụ isi ihe na-egosi thrombosis miri emi (DVT), pulmonary embolism (PE), mgbasa nke intravascular coagulation (DIC).

Ọtụtụ ọrịa na-akpata mkpali nke usoro coagulation na/ma ọ bụ sistemụ fibrinolytic n'ahụ, na-ebute mmụba na ọkwa D-dimer, mkpali a na-ejikọkwa ya na ọkwa, oke na ọgwụgwọ nke ọrịa ahụ, yabụ n'ọrịa ndị a, enwere ike iji nchọpụta nke ọkwa D-dimer dị ka ihe nrịbama nyocha maka nhazi ọrịa, amụma na nduzi ọgwụgwọ.

Itinye D-dimer n'ọrụ n'ọgwụ thrombosis miri emi nke akwara miri emi

Ebe ọ bụ na Wilson na ndị otu ya tinyere ngwaahịa fibrin degeneration maka nchọpụta nke pulmonary embolism na 1971, nchọpụta nke D-dimer arụọla ọrụ dị ukwuu na nchọpụta nke pulmonary embolism. Site na ụfọdụ ụzọ nchọpụta dị oke mkpa, uru ahụ D-dimer na-adịghị mma nwere mmetụta amụma na-adịghị mma maka pulmonary embolism, uru ya dịkwa 0.99. Nsonaazụ na-adịghị mma nwere ike iwepụ pulmonary embolism, si otú a belata nyocha ndị na-awakpo, dị ka nyocha ikuku ventilashion perfusion na pulmonary angiography; zere ọgwụgwọ anticoagulation kpuru ìsì.D - Njupụta nke dimer metụtara ebe thrombus dị, yana nnukwu njupụta na alaka ndị bụ isi nke pulmonary pulmonary na obere njupụta na obere alaka.

D-dimers plasma na-adịghị mma na-ewepụ ohere nke DVT. Angiography kwadoro na DVT dị mma 100% maka D-dimer. Enwere ike iji ya maka ọgwụgwọ thrombolytic na nduzi ọgwụ heparin anticoagulation na nlele arụmọrụ.

D-dimer nwere ike igosi mgbanwe na nha thrombus. Ọ bụrụ na ọdịnaya ahụ amụbaa ọzọ, ọ na-egosi nlọghachi nke thrombus; n'oge ọgwụgwọ ahụ, ọ na-aga n'ihu na-adị elu, nha thrombus anaghị agbanwe agbanwe, nke na-egosi na ọgwụgwọ ahụ adịghị arụ ọrụ nke ọma.