Ib lub cev ib txwm muaj ib qho kev coagulation thiab anticoagulation system tiav. Lub coagulation system thiab anticoagulation system tswj hwm qhov sib npaug ntawm lub cev kom ntseeg tau tias lub cev hemostasis thiab cov ntshav ntws zoo. Thaum qhov sib npaug ntawm coagulation thiab anticoagulation function raug cuam tshuam, nws yuav ua rau los ntshav thiab thrombosis.

1. Lub cev ua haujlwm coagulation

Lub cev coagulation feem ntau yog tsim los ntawm cov yam ntxwv coagulation. Cov tshuaj uas cuam tshuam ncaj qha rau kev coagulation hu ua coagulation factors. Muaj 13 yam coagulation factors uas paub zoo.

Muaj cov kev ua kom muaj zog endogenous thiab cov kev ua kom muaj zog sab nraud rau kev ua kom cov coagulation factors ua haujlwm.

Tam sim no ntseeg tau tias qhov kev ua haujlwm ntawm lub cev coagulation sab nraud uas pib los ntawm cov ntaub so ntswg ua lub luag haujlwm tseem ceeb hauv kev pib ntawm coagulation. Kev sib txuas ze ntawm cov txheej txheem coagulation sab hauv thiab sab nraud ua lub luag haujlwm tseem ceeb hauv kev pib thiab tswj cov txheej txheem coagulation.

2. Lub cev ua haujlwm tiv thaiv kev coagulation

Cov txheej txheem tiv thaiv kev coagulation suav nrog cov txheej txheem tiv thaiv kev coagulation ntawm tes thiab cov kua dej hauv lub cev.

①Cell anticoagulation system

Hais txog phagocytosis ntawm coagulation factor, tissue factor, prothrombin complex thiab soluble fibrin monomer los ntawm mononuclear-phagocyte system.

②Lub cev kua dej tiv thaiv kev coagulation system

Xws li: serine protease inhibitors, protein C-based protease inhibitors thiab tissue factor pathway inhibitors (TFPI).

3. Lub cev fibrinolytic thiab nws cov haujlwm

Feem ntau suav nrog plasminogen, plasmin, plasminogen activator thiab fibrinolysis inhibitor.

Lub luag haujlwm ntawm lub cev fibrinolytic: yaj cov fibrin clots thiab xyuas kom meej tias cov ntshav ncig zoo; koom nrog kev kho cov ntaub so ntswg thiab kev tsim cov hlab ntsha.

4. Lub luag haujlwm ntawm cov hlwb endothelial ntawm cov hlab ntsha hauv cov txheej txheem ntawm kev coagulation, anticoagulation thiab fibrinolysis

① Tsim ntau yam tshuaj lom neeg;

② Tswj cov ntshav coagulation thiab anticoagulation muaj nuj nqi;

③ Kho qhov kev ua haujlwm ntawm fibrinolysis system;

④ Tswj kev nruj ntawm cov hlab ntsha;

⑤Koom nrog kev sib hais haum ntawm kev o;

⑥Txhawb nqa kev ua haujlwm ntawm microcirculation, thiab lwm yam.

Cov teeb meem ntawm kev coagulation thiab anticoagulant

1. Tej yam tsis zoo ntawm cov ntshav coagulation.

2. Qhov tsis zoo ntawm cov tshuaj anticoagulant hauv cov ntshav.

3. Qhov tsis zoo ntawm cov tshuaj fibrinolytic hauv cov ntshav.

4. Tej yam tsis zoo ntawm cov qe ntshav.

5. Cov hlab ntsha tsis zoo li qub.