ʻO FIB ka pōkole Pelekane no fibrinogen, a ʻo fibrinogen kahi kumu coagulation. ʻO ka waiwai FIB coagulation koko kiʻekiʻe ʻo ia hoʻi ke koko i loko o kahi kūlana hypercoagulable, a maʻalahi ka hana ʻana o nā thrombus.
Ma hope o ka hoʻāla ʻia ʻana o ke ʻano coagulation kanaka, lilo ka fibrinogen i fibrin monomer ma lalo o ka hana a thrombin, a hiki i ka fibrin monomer ke hōʻuluʻulu i loko o ka fibrin polymer, he mea kōkua ia no ka hoʻokumu ʻana o ke koko clot a he kuleana koʻikoʻi i ke kaʻina hana coagulation.
Hoʻohui nui ʻia ka Fibrinogen e nā hepatocytes a he protein me ka hana coagulation. ʻO kona waiwai maʻamau ma waena o 2 ~ 4qL. He mea pili i ka coagulation ka Fibrinogen, a ʻo kona hoʻonui pinepine ʻana he hopena kikoʻī ʻole ia o ke kino a he mea pilikia ia no nā maʻi e pili ana i ka thromboembolism.
Hiki ke hoʻonui ʻia ka waiwai Coagulation FIB i nā maʻi he nui, nā kumu genetic maʻamau a i ʻole nā mea mumū, nā lipids koko kiʻekiʻe, ke koko koko
ʻO ke kiʻekiʻe, ka maʻi puʻuwai coronary, ka maʻi diabetes, ka maʻi puʻupuʻu, ka maʻi pili o nā ʻiʻo, ka maʻi puʻuwai, a me nā puʻupuʻu ʻino. i ka wā e loaʻa ai i nā maʻi āpau i luna aʻe e alakaʻi ai i ka hanana ʻana o nā clots koko. No laila, ʻo ka waiwai FIB coagulation koko kiʻekiʻe e pili ana i ke kūlana o ka coagulation koko kiʻekiʻe.
ʻO ke kiʻekiʻe o ka pae fibrinogen, ʻo ia hoʻi, aia ke koko i loko o kahi kūlana hypercoagulability a he maʻalahi hoʻi i ka thrombosis. Ua ʻike ʻia ʻo Fibrinogen ʻo ia hoʻi ka coagulation factor I. Inā he endogenous coagulation a exogenous coagulation paha, ʻo ka hana hope loa o ka fibrinogen e hoʻāla i nā fibroblasts. Hoʻopili mālie ʻia nā protein i loko o kahi pūnaewele e hana i nā clots koko, no laila ke hōʻike nei ka fibrinogen i ka hana o ke coagulation koko.
Hoʻohui nui ʻia ka Fibrinogen e ke akepaʻa a hiki ke hoʻokiʻekiʻe ʻia i nā maʻi he nui. ʻO nā mea hoʻoilina maʻamau a i ʻole nā mea mumū e komo pū me nā lipids koko kiʻekiʻe, ke koko kiʻekiʻe, ka maʻi puʻuwai coronary, ka maʻi diabetes, ka maʻi puʻupuʻu, ka maʻi pili, ka maʻi puʻuwai, a me nā maʻi ʻino e piʻi aʻe. Ma hope o ke ʻoki kino nui, no ka mea pono ke kino e hana i ka hana hemostasis, e hoʻoulu pū ia i ka hoʻonui ʻia o ka fibrinogen no ka hana hemostasis.
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