Ke kaʻina hana thrombosis, me 2 mau kaʻina hana:

1. Hoʻopili a me ka hōʻuluʻulu ʻana o nā platelets i loko o ke koko

I ke kahua mua o ka thrombosis, hoʻomau ʻia nā platelets mai ke kahe axial a pili i ka ʻili o nā olonā collagen i hōʻike ʻia ma ka intima o nā kīʻaha koko i hōʻino ʻia. Hoʻāla ʻia nā platelets e ka collagen a hoʻokuʻu i nā mea e like me ADP, thromboxane A2, 5-AT a me ka platelet factor IV. , Loaʻa i kēia mau mea ka hopena ikaika o ka agglutinating platelets, i hoʻomau nā platelets i loko o ke koko e agglutinate kūloko e hana i kahi puʻu platelet. , ka hoʻomaka ʻana o ka venous thrombosis, ke poʻo o ka thrombus.

Hoʻopili nā platelets i ka ʻili o nā olonā collagen i hōʻike ʻia ma ka intima o ke kīʻaha koko i hōʻino ʻia a hoʻāla ʻia e hana i kahi puʻu platelet e like me ka puʻu. Hoʻonui mālie ka puʻu a hui pū me nā leukocytes e hana i kahi thrombus keʻokeʻo. Loaʻa iā ia nā leukocytes hou aʻe i hoʻopili ʻia i kona ʻili. Hoʻolohi mālie ke kahe ʻana o ke koko, hoʻāla ʻia ka ʻōnaehana coagulation, a he nui ka fibrin e hana i kahi ʻano pūnaewele, kahi e hopu ai i nā hunaola koko ʻulaʻula a me nā hunaola koko keʻokeʻo e hana i kahi thrombus i hui pū ʻia.

2. Hoʻopili koko

Ma hope o ka hoʻokumu ʻia ʻana o ka thrombus keʻokeʻo, puka mai ia i loko o ka lumen vascular, e hoʻolohi ana i ke kahe koko ma hope ona a ʻike ʻia he whirlpool, a hoʻokumu ʻia kahi puʻu platelet hou ma ka whirlpool. ʻO nā trabeculae, i ke ʻano e like me ke korala, he nui nā leukocytes i hoʻopili ʻia i ko lākou ʻili.

Hoʻolohi mālie ke kahe koko ma waena o nā trabeculae, hoʻāla ʻia ka ʻōnaehana coagulation, a piʻi mālie ka nui o nā mea coagulation kūloko a me nā mea platelet, e hana ana a ulana ʻia i loko o kahi ʻano mesh ma waena o nā trabeculae. Keʻokeʻo a keʻokeʻo, corrugated i hui pū ʻia e hana ana i ke kino o ka thrombus.

Ua hoʻonui mālie ʻia ka thrombus i hui ʻia a hoʻolōʻihi ʻia i ke kuhikuhi o ke kahe ʻana o ke koko, a ma hope ua ālai loa i ka lumen o nā kīʻaha koko, e hoʻōki ana i ke kahe o ke koko.