Ke alakaʻi ka hana coagulation maikaʻi ʻole o ka mea maʻi i ke kahe koko, hiki ke kumu ʻia e ka emi ʻana o ka hana coagulation. Pono ka hoʻāʻo ʻana i nā kumu coagulation. Ua maopopo he kumu ke kahe koko ma muli o ka nele o nā kumu coagulation a i ʻole nā ​​​​​​mea anticoagulation hou aʻe. Wahi a ke kumu, hoʻohui i nā mea coagulation like a i ʻole plasma hou. ʻO ke alo o nā mea clotting hou aʻe hiki ke kōkua i ka hoʻōki ʻana i ke kahe koko. Ma ke ʻano lapaʻau, hiki ke ʻike ʻia inā ua emi nā mea coagulation like o nā ala coagulation kūloko a me waho o ka hana coagulation a i ʻole he hana hewa, a nānā inā ua kumu ʻia ka hana coagulation maʻamau e ka nele o nā mea coagulation a i ʻole ka hana o nā mea coagulation, ʻo ia hoʻi nā kūlana penei:

1. Ke ala coagulation endogenous maʻamau ʻole: ʻO ke kumu coagulation nui e hoʻopilikia ana i ke ala coagulation endogenous ʻo APTT. Inā hoʻolōʻihi ʻia ka APTT, ʻo ia hoʻi he mau kumu coagulation maʻamau ʻole i ke ala endogenous, e like me ka factor 12, factor 9, factor 8, a me ke ala maʻamau 10. Hiki i ka hemahema o ka factor ke hana i nā hōʻailona kahe koko i nā maʻi;

2. Ke ala coagulation extrinsic maʻamau ʻole: inā hoʻolōʻihi ʻia ka PT, hiki ke ʻike ʻia he ʻano ʻē paha ka tissue factor, factor 5 a me ka factor 10 ma ke ala maʻamau, ʻo ia hoʻi, ʻo ka emi ʻana o ka helu e alakaʻi ai i ka manawa coagulation lōʻihi a hoʻoulu i ke kahe koko i ka mea maʻi.