Jiki na yau da kullun yana da cikakken tsarin coagulation da anticoagulation. Tsarin coagulation da tsarin anticoagulation suna kiyaye daidaiton motsi don tabbatar da hemostasis na jiki da kuma gudanawar jini mai santsi. Da zarar an sami matsala a daidaita aikin coagulation da anticoagulation, zai haifar da zubar jini da kuma yanayin thrombosis.

1. Aikin hada jini a jiki

Tsarin coagulation ya ƙunshi abubuwan coagulation. Abubuwan da ke cikin coagulation kai tsaye ana kiransu abubuwan coagulation. Akwai abubuwa 13 da aka gane suna coagulation.

Akwai hanyoyin kunnawa na ciki da hanyoyin kunnawa na waje don kunna abubuwan haɗin jini.

A halin yanzu ana kyautata zaton cewa kunna tsarin coagulation na waje wanda sinadarin nama ya fara yana taka muhimmiyar rawa wajen fara coagulation. Hulɗar da ke tsakanin tsarin coagulation na ciki da na waje yana taka muhimmiyar rawa wajen fara da kuma kula da tsarin coagulation.

2. Aikin hana zubar jini na jiki

Tsarin hana zubar jini ya haɗa da tsarin hana zubar jini ta sel da tsarin hana zubar jini ta ruwa.

① Tsarin hana zubar jini na ƙwayoyin halitta

Yana nufin phagocytosis na coagulation factor, tissue factor, prothrombin complex da soluble fibrin monomer ta hanyar mononuclear-phagocyte tsarin.

② Tsarin hana zubar jini na ruwa

Ya haɗa da: masu hana sinadarin serine protease, masu hana sinadarin protease mai tushen furotin C da kuma masu hana tasirin tissue factor (TFPI).

3. Tsarin Fibrinolytic da ayyukansa

Galibi sun haɗa da plasminogen, plasmin, plasminogen activator da fibrinolysis inhibitor.

Matsayin tsarin fibrinolytic: yana narkar da ƙwayoyin fibrinolytic kuma yana tabbatar da santsi na zagayawar jini; yana shiga cikin gyaran kyallen takarda da kuma sake farfaɗo da jijiyoyin jini.

4. Matsayin ƙwayoyin endothelial na jijiyoyin jini a cikin tsarin coagulation, anticoagulation da fibrinolysis

① Samar da abubuwa daban-daban masu aiki a fannin ilmin halitta;

② Daidaita aikin coagulation na jini da kuma aikin hana coagulation;

③Daidaita aikin tsarin fibrinolysis;

④ Daidaita tashin hankali na jijiyoyin jini;

⑤ Shiga cikin maganin kumburi;

⑥Kula da aikin microcirculation, da sauransu.

Matsalolin da ke tattare da coagulation da kuma aikin coagulation

1. Matsalolin da ke tattare da abubuwan da ke haifar da coagulation.

2. Rashin daidaituwar abubuwan da ke hana zubar jini a cikin jini.

3. Rashin daidaituwar sinadarin fibrinolytic a cikin jini.

4. Matsalolin ƙwayoyin jini.

5. Jijiyoyin jini marasa tsari.