Ngokwezokwelapha, "ukujiya" kuyinqubo eyinkimbinkimbi yomzimba, ebhekisela ochungechungeni lwezindlela lapho igazi lishintsha khona lisuka koketshezi liye ekujiya kwegazi okuqinile okufana nejeli. Inhloso eyinhloko ukumisa ukopha nokuvimbela ukulahleka kwegazi ngokweqile. Okulandelayo incazelo eningiliziwe evela ezicini zezici zokujiya, inqubo yokujiya kanye nendlela yokujiya okungavamile:

1-Izici zokubopha igazi: Kunezinto eziningi zokubopha igazi, njenge-factor I (fibrinogen), i-factor II (prothrombin), i-factor V, i-factor VII, i-factor VIII, i-factor IX, i-factor X, i-factor XI, i-factor XII, njll. Iningi lazo lenziwa esibindini. Lezi zici zokubopha igazi zidlala indima ebalulekile enqubweni yokubopha igazi, futhi ngochungechunge lwezenzo kanye nokusebenzisana, igazi ekugcineni liyaboshwa.

Inqubo yokujiya kwezicubu: Ingahlukaniswa ibe yindlela yokujiya kwezicubu ezingaphakathi kanye nendlela yokujiya kwezicubu ezingaphandle. Zombili lezi zindlela zigcina zihlangana zibe yindlela evamile yokujiya kwezicubu ukuze zakhe i-thrombin, eguqula i-fibrinogen ibe yi-fibrin ukuze kwakheke ihlule legazi.
(1) Indlela yokujiya kwangaphakathi: Lapho i-endothelium yemithambo yegazi yonakele futhi igazi lithintana nemicu ye-collagen eveziwe ye-subendothelial, i-factor XII iyavuselelwa, kuqala indlela yokujiya kwangaphakathi. I-Factor XI, i-factor IX, i-factor X, njll. bese ivuselelwa ngokulandelana, futhi ekugcineni, ebusweni be-phospholipid obunikezwa ama-platelet, i-factor X, i-factor V, ama-ion e-calcium kanye nama-phospholipid ndawonye kwakha i-prothrombin activator.

(2) Indlela yokujiya kwangaphandle: Iqalwa ukukhululwa kwe-tissue factor (TF) ngomonakalo wezicubu. I-TF ihlangana ne-factor VII ukwakha i-TF-VII complex, evuselela i-factor X bese yakha i-prothrombin activator. Indlela yokujiya kwangaphandle ishesha kunendlela yokujiya kwangaphakathi futhi ingabangela ukuba igazi lijiye ngesikhathi esifushane.

(3) Indlela evamile yokujiya: Ngemva kokuba i-activator ye-prothrombin yakheke, i-prothrombin ivuselelwa ibe yi-thrombin. I-Thrombin iyisici esiyinhloko sokujiya esikhuthaza ukuguqulwa kwe-fibrinogen ibe yi-fibrin monomers. Ngaphansi kwesenzo se-factor XIII kanye ne-calcium ions, ama-fibrin monomers ayahlangana ukuze akhe ama-fibrin polymer azinzile. Lawa ma-fibrin polymer ahlanganiswe abe yinethiwekhi, abambe amaseli egazi ukuze akhe amahlule egazi futhi aqedele inqubo yokujiya.

3-Indlela engavamile yokubopha ama-coagulation: okuhlanganisa ukuphazamiseka kokubopha ama-coagulation kanye nokuphazamiseka kokubopha ama-coagulation.
(1) Ukujiya kwegazi: Umzimba usesimweni sokujiya kwegazi futhi uthambekele ekushayweni kwegazi okukhulu. Isibonelo, ezimweni zokulimala okukhulu, ukuhlinzwa okukhulu, izimila ezinobungozi, njll., umsebenzi wezinto ezijiya igazi kanye nama-platelet egazini uyakhula, futhi ukujiya kwegazi kuyakhuphuka, okungaholela kalula ekushayweni kwegazi okukhulu, okungase kubangele izifo ezinkulu ezifana ne-pulmonary embolism, i-cerebral infarction, i-myocardial infarction, njll., futhi kubeke impilo engozini.

(2) Isifo sokujiya kwegazi: sibhekisela ekushodeni noma ekusebenzeni okungajwayelekile kwezinto ezithile ezijiya igazi enqubweni yokujiya kwegazi, okuholela ekwandeni kokuthambekela kokopha. Izimbangela ezivamile zifaka phakathi ukuntuleka kwezinto ezijiya igazi, njenge-hemophilia A (ukuntuleka kwe-factor VIII) kanye ne-hemophilia B (ukuntuleka kwe-factor IX); ukuntuleka kwe-vitamin K, okuthinta ukwakheka kwezinto II, VII, IX, kanye no-X; isifo sesibindi, okuholela ekwehleni kokwakheka kwezinto ezijiya igazi; kanye nokusetshenziswa kwama-anticoagulants, njenge-warfarin kanye ne-heparin, okuvimbela inqubo yokujiya kwegazi.

Ukuqina kwemithambo yegazi kudlala indima ebalulekile ekugcineni ukusebenza okuvamile komzimba womuntu. Noma yikuphi ukungajwayelekile kokusebenza kokuqina kwemithambo yegazi kungaba nomthelela omkhulu empilweni. Emtholampilo, izivivinyo ezahlukahlukene zokuqina kwemithambo yegazi, njengesikhathi se-prothrombin (PT), isikhathi se-activated partial thromboplastin (APTT), ukunqunywa kwe-fibrinogen, njll., kuvame ukusetshenziswa ukuhlola ukusebenza kokuqina kwemithambo yegazi yesiguli, ukuze kutholakale futhi kwelashwe izifo ezihlobene nokuqina kwemithambo yegazi ngesikhathi esifanele.