UKUHLOLWA KWESIKHUNGO SOKUXHUMANA KWESIKHUNGO
ISICELO SOKUHLAZIYA IZINTO EZINGAKUSETSHENZISWA
Ukuqapha kahle imithi ye-heparin kuyisayensi kanye nobuciko, futhi kuhlobene ngqo nempumelelo noma ukwehluleka kokwelashwa kwe-anticoagulant.
Imithi ye-Heparin ivame ukusetshenziswa njengemithi yokulwa nokuvuvukala kwegazi ukuvimbela nokwelapha izifo ze-thromboembolic futhi isetshenziswa kabanzi emikhakheni eminingi yezokwelapha.
Kodwa-ke, indlela yokusebenzisa kahle nokuqapha ngokufanele le mithi ukuqinisekisa ukuphepha nokusebenza kahle kokwelashwa bekulokhu kugxilwe kodokotela.
Okukhishwe muva nje "Ukuvumelana Kochwepheshe Ngokuqaphelwa Kwemithi Ye-Heparin Emtholampilo"Ngixoxe ngokugcwele ngezinkomba, umthamo, ukuqapha kanye nezinye izici zemithi ye-heparin, ikakhulukazi ngicacise izindlela zokusebenzisa emtholampilo zezinkomba zelebhu ezifana nomsebenzi we-anti-Xa."
Lesi sihloko sizofingqa amaphuzu abalulekile alesi sivumelwano ukuze sisize abasebenzi bezokwelapha ukuthi basebenzise kangcono lokhu.
1-Ukukhethwa kwezinkomba zokuqapha elebhu
Ukuvumelana kugcizelela ukuthi izinto ezijwayelekile okufanele ziqashwe ngaphambi nangesikhathi sokusetshenziswa kwemithi ye-heparin zifaka phakathi kodwa azigcini nje nge-hemodynamics, ukusebenza kwezinso, i-hemoglobin, inani lama-platelet kanye negazi elingabonakali esithweni sangasese.
Amaphuzu ama-2 ayisihluthulelo okuqapha izidakamizwa ezahlukene ze-heparin
(1) I-heparin engahlukaniswanga (UFH)
Umthamo wokwelapha we-UFH kumele uqashwe futhi umthamo ulungiswe ngokuya ngomsebenzi we-anticoagulant.
Ukuqapha i-ACT kusetshenziselwa ukusetshenziswa kwemithamo ephezulu (njengasesikhathini se-PCI kanye nokujikeleza kwegazi ngaphandle komzimba [CPB]).
Kwezinye izimo (njengokwelashwa kwe-ACS noma i-VTE), i-APTT elungisiwe yomsebenzi we-anti-Xa noma we-anti-Xa ingakhethwa.
(2) I-heparin enesisindo sama-molecule esiphansi (LMWH)
Ngokwezici ze-pharmacokinetic ze-LMWH, ukuqapha njalo umsebenzi we-anti-Xa akudingeki.
Kodwa-ke, iziguli ezinesisindo somzimba esiphezulu noma esiphansi, ukukhulelwa, noma ukwehluleka kwezinso kudingeka zihlolwe ngokuphepha noma zilungiswe umthamo ngokusekelwe emsebenzini wokulwa noXa.
(3) Ukuqapha i-sodium ye-Fondaparinux
Iziguli ezisebenzisa imithamo yokuvimbela noma yokwelapha ye-fondaparinux sodium azidingi ukuqashwa njalo komsebenzi we-anti-Xa, kodwa ukuqashwa komsebenzi we-anti-Xa kuyanconywa ezigulini ezikhuluphele ezinokwehluleka kwezinso.
3- Ukumelana ne-Heparin kanye nokwelashwa kwe-HIT
Uma kusolwa ukuthi kukhona ukuntuleka kwe-antithrombin (AT) noma ukumelana ne-heparin, kunconywa ukuthi kuhlolwe amazinga omsebenzi we-AT ukuze kukhishwe ukuntuleka kwe-AT futhi kuqondiswe ukwelashwa okudingakalayo.
Kunconywa ukusebenzisa i-chromogenic substrate assay esekelwe ku-IIa (equkethe i-bovine thrombin) noma i-Xa yomsebenzi we-AT.
Ezigulini ezisolwa ngokwezokwelapha nge-thrombocytopenia ebangelwa yi-heparin (HIT), ukuhlolwa kwe-antibody ye-HIT ngokuvamile akukhuthazwa ezigulini ezitholakale zinesifo se-UFH ezinethuba eliphansi le-HIT (amaphuzu angu-≤3) ngokusekelwe kumaphuzu angu-4T.
Kuziguli ezinethuba eliphakathi kuya kweliphezulu le-HIT (amaphuzu angu-4-8), kunconywa ukuhlolwa kwe-antibody ye-HIT.
Kunconywa umkhawulo ophezulu wokuhlolwa kwe-antibody exubile, kanti umkhawulo ophansi unconywa wokuhlolwa kwe-antibody ethize ye-IgG.
4- Ukuphathwa Kwengozi Yokopha kanye Nokwelashwa Okuguqulayo
Uma kwenzeka ukopha okukhulu okuhlobene ne-heparin, imithi yokulwa nokuphazamiseka kwegazi kufanele iyekwe ngokushesha, futhi ukuzinza kwe-hemostasis kanye ne-hemodynamic kufanele kugcinwe ngokushesha ngangokunokwenzeka.
I-Protamine inconywa njengokwelashwa kokuqala kokunciphisa i-heparin.
Isilinganiso se-protamine kufanele sibalwe ngokusekelwe esikhathini sokusetshenziswa kwe-heparin.
Nakuba zingekho izindlela ezithile zokuqapha i-protamine, ukuhlolwa kwezokwelapha komphumela wokuguqula i-protamine kungenziwa ngokubheka isimo sokopha kwesiguli kanye nezinguquko ku-APTT.
Ayikho ikhambi elithile le-fondaparinux sodium; imiphumela yayo yokulwa nokujiya kwegazi ingaguqulwa kusetshenziswa i-FFP, i-PCC, i-rFVIIa, ngisho ne-plasma exchange.
Lokhu kuvumelana kunikeza izinqubo zokuqapha ezinemininingwane kanye namanani aqondiwe, okusisiza ukuthi senze izinqumo ezinembile kakhulu ekusebenzeni kwezokwelapha.
Ukwelashwa nge-anticoagulant kuyinkemba esika nhlangothi zombili: ukusetshenziswa okufanele kungavimbela futhi kwelaphe izifo ze-thrombotic, kodwa ukusetshenziswa okungafanele kungandisa ingozi yokopha.
Sithemba ukuthi ukuhumusha lokhu kuvumelana kuzokusiza ukuthi uphumelele kakhudlwana emtholampilo futhi unikeze ukwelashwa okuphephile futhi okuphumelelayo kwe-anticoagulant ezigulini zakho.
I-Beijing Succeeder Technology Inc. (ikhodi yesitoko: 688338) ibilokhu ihileleke kakhulu emkhakheni wokuxilongwa kokuqina kwegazi selokhu yasungulwa ngo-2003, futhi izibophezele ekubeni ngumholi kulo mkhakha. Indlunkulu yayo eBeijing, inethimba eliqinile le-R&D, lokukhiqiza kanye nelokuthengisa, eligxile ekusungulweni nasekusetshenzisweni kobuchwepheshe bokuxilonga i-thrombosis kanye ne-hemostasis.
Ngenxa yamandla ayo obuchwepheshe avelele, iSucceeder iwine amalungelo obunikazi angu-45 agunyaziwe, okuhlanganisa amalungelo obunikazi okusungula angu-14, amalungelo obunikazi angu-16 emodeli yokusetshenziswa kanye namalungelo obunikazi okuklama angu-15.
Le nkampani futhi inezitifiketi zokubhaliswa komkhiqizo wedivayisi yezokwelapha zeSigaba II ezingama-32, izitifiketi zokufaka izicelo zeSigaba I ezi-3, kanye nesitifiketi se-EU CE semikhiqizo eyi-14, futhi iphumelele isitifiketi sesistimu yokuphatha ikhwalithi ye-ISO 13485 ukuqinisekisa ubuhle kanye nokuzinza kwekhwalithi yomkhiqizo.
I-Succeeder ayiyona nje inkampani ebalulekile ye-Beijing Biomedicine Industry Leapfrog Development Project (G20), kodwa futhi iphumelele ekufinyeleleni kwiBhodi Yezesayensi Nobuchwepheshe Bokusungula Izinto ezintsha ngo-2020, yafinyelela intuthuko eshesha kakhulu kule nkampani.
Njengamanje, inkampani yakhe inethiwekhi yokuthengisa kazwelonke ehlanganisa amakhulu ama-ejenti namahhovisi.
Imikhiqizo yayo ithengiswa kahle ezindaweni eziningi zezwe.
Futhi ikhulisa ngenkuthalo izimakethe zaphesheya kwezilwandle futhi ithuthukisa njalo ukuncintisana kwayo kwamazwe ngamazwe.
Ikhadi lebhizinisi
I-WeChat yesiShayina