Ukuba ukopha okungaphantsi komzimba kwenzeka ngexesha elifutshane kwaye indawo iqhubeka nokwanda, ihamba nokopha kwezinye iindawo, njengokuphuma kwegazi empumlweni, ukopha kwamathumbu, ukopha okuphuma emqolo, i-hematuria, njl.njl.; Izinga lokufunxa liyancipha emva kokopha, kwaye indawo yokopha ayinciphi kancinci kangangeeveki ezingaphezu kwezimbini; Ihamba nezinye iimpawu, ezifana ne-anemia, umkhuhlane, njl.njl.; Kucetyiswa ukuba ufune uncedo lwezonyango kwicandelo le-hematology ukuba kukho ukopha okuphindaphindiweyo ukususela ebuntwaneni kunye neempawu ezifanayo kusapho.

Abantwana abangaphantsi kweminyaka eli-14 ubudala abafumana ezi mpawu zingasentla bayacetyiswa ukuba bafune uncedo lwezonyango kwizikolo zabantwana.

Ukuba ukopha okungaphantsi komhlaba kubonakala njenge-ecchymosis yesikhumba kunye ne-mucosal, kunye neempawu zokopha kwamathumbu ezifana nokopha empumlweni nasesiswini, igazi eligabhayo, kunye nokopha okuphuma emqolo, okuhamba nesicaphucaphu, i-anorexia, ukudumba, ukubhitya, ukuhambahamba, ukutyheli kolusu kunye ne-sclera, kunye nokuqokelelwa kolwelo lwesisu, kuthathwa njengokuphuma kwegazi okungaphantsi komhlaba okubangelwa kukonakala komsebenzi wesibindi, i-cirrhosis, ukungasebenzi kakuhle kwesibindi, njl. Kucetyiswa ukuba ufune uncedo lwezonyango kwicandelo le-gastroenterology.