KUONGORORA KWEKUVANDUDZA KWEMASHONGA EKUCHENGETEDZA
KUSHANDISA KWEMA REAGENTS EKUONGORORA
Kutarisa mishonga yeheparin nemazvo inyaya yesainzi uye hunyanzvi, uye zvine chekuita nekubudirira kana kukundikana kwekurapa nemishonga inorwisa ropa.
Mishonga yeHeparin inowanzo shandiswa kudzivirira nekurapa zvirwere zve thromboembolic uye inoshandiswa zvakanyanya muzvipatara zvakawanda.
Zvisinei, mashandisirwo nemazvo uye kutarisa zvine musoro mishonga iyi kuti ive nechokwadi chekuti kurapwa kwakachengeteka uye kushanda zvakanaka kwagara kuri chinangwa chevanachiremba.
"Yakaburitswa munguva pfupi yapfuura"Kubvumirana kweNyanzvi paKutarisa Mishonga yeHeparin muMakiriniki"Akakurukura zvizere zviratidzo, chiyero, kutarisa uye zvimwe zvinhu zvemishonga yeheparin, kunyanya akajekesa nzira dzekushandisa zviratidzo zverabhoritari senge anti-Xa activity.
Chinyorwa chino chichapfupikisa pfungwa huru dzechibvumirano ichi kuti chibatsire vashandi vekiriniki kuchishandisa zviri nani.
1-Kusarudzwa kwezviratidzo zvekutarisa murabhoritari
Kubvumirana kunosimbisa kuti zvinhu zvakajairika zvinofanira kutariswa usati washandisa mishonga yeheparin uye panguva yekushandisa zvinosanganisira asi hazvingogumiri pa hemodynamics, mashandiro eitsvo, hemoglobin, huwandu hwemaplatelet uye ropa remutsvina.
2-Pfungwa dzinokosha dzekutarisa mishonga yakasiyana yeheparin
(1) Heparin isina kupatsanurwa (UFH)
Chipimo chekurapa cheUFH chinofanira kutariswa uye chipimo chacho chinofanira kugadziriswa zvichienderana nebasa rekudzivirira ropa.
Kuongororwa kweACT kunoshandiswa pakushandisa mishonga yakawanda (senge panguva yePCI uye kutenderera kweropa kunze kwemuviri [CPB]).
Mune mamwe mamiriro ezvinhu (akadai sekurapa ACS kana VTE), APTT yakagadziriswa yekurwisa Xa kana anti-Xa activity inogona kusarudzwa.
(2) Heparin ine huremu hushoma (LMWH)
Zvichienderana nehunhu hwemishonga hweLMWH, hazvidiwi kuti munhu aongorore nguva dzose mashandiro ekurwisa Xa.
Zvisinei, varwere vane huremu hwakakwira kana hushoma, vane pamuviri, kana kuti vane dambudziko reitsvo vanofanirwa kuongororwa zvakachengeteka kana kugadziriswa kwemushonga zvichienderana nemaitiro ekurwisa Xa.
(3) Kuongororwa kweFondaparinux sodium
Varwere vanoshandisa fondaparinux sodium kudzivirira kana kurapa havadi kuongororwa nguva dzose kwemabasa ekurwisa Xa, asi kuongororwa kwemabasa ekurwisa Xa kunokurudzirwa kune varwere vakafuta vane dambudziko reitsvo.
3- Kurapwa kweHeparin neHIT
Kana paine fungidziro yekuti hapana antithrombin (AT) kana kuti heparin resistance, zvinokurudzirwa kuti uedze AT activity levels kuti usashandise AT shoulder uye utungamirire mushonga wekutsiva unodiwa.
Zvinokurudzirwa kushandisa chromogenic substrate assay yakavakirwa paIIa (ine bovine thrombin) kana Xa pakuita AT activity.
Kune varwere vanofungidzirwa kuti vane heparin-induced thrombocytopenia (HIT), kuongororwa kweHIT antibody hakukurudzirwi kune varwere vane UFH-exposed vane mukana wakaderera weHIT (≤3 points) zvichibva pa4T score.
Kune varwere vane mukana wepakati kusvika wepamusoro weHIV (4-8 points), kuongororwa kweHIT antibody kunokurudzirwa.
Muganho wepamusoro unokurudzirwa pakuongororwa kwemasoja emuviri akasiyana-siyana, nepo muganho wepasi uchikurudzirwa pakuongororwa kwemasoja emuviri akasiyana-siyana eIgG.
4- Kutarisira Njodzi Dzekubuda Kweropa uye Kurapa Kwekuchinja
Kana ropa rakawanda rikabuda nekuda kweheparin, mishonga inoderedza thrombosis inofanira kuregwa nekukasika, uye kugadzikana kwe hemostasis ne hemodynamic kunofanira kuchengetedzwa nekukurumidza sezvinobvira.
Protamine inokurudzirwa senzira yekutanga yekurapa heparin inobvisa ganda.
Chipimo cheprotamine chinofanira kuverengerwa zvichienderana nenguva yekushandiswa kweheparin.
Kunyange hazvo pasina nzira dzakatarwa dzekutarisa protamine, kuongororwa kwekiriniki kwemhedzisiro yeprotamine kunogona kuitwa nekutarisa mamiriro ekubuda ropa kwemurwere uye shanduko muAPTT.
Hapana mushonga chaiwo we fondaparinux sodium; mhedzisiro yayo yekudzora ropa rinogona kuchinjwa uchishandisa FFP, PCC, rFVIIa, uye kunyange plasma exchange.
Kubvumirana uku kunopa nzira dzakadzama dzekutarisa uye kukosha kwezvinangwa, zvichitibatsira kuita sarudzo dzakanyatsojeka mukurapa.
Kurapa nemishonga inorwisa ropa rinocheka nepakati: kushandisa zvakanaka kunogona kudzivirira nekurapa zvirwere zveropa, asi kushandisa zvisina kunaka kunogona kuwedzera njodzi yekubuda ropa.
Tinovimba kuti kududzira kubvumirana uku kuchakubatsira kuti ubudirire mukurapa uye kupa mushonga wakachengeteka uye unoshanda wekudzivirira ropa kuvarwere vako.
Beijing Succeeder Technology Inc. (kodhi yemasheya: 688338) yave ichibatanidzwa zvakanyanya mubazi rekuongorora ropa kubva payakatangwa muna 2003, uye yakazvipira kuva mutungamiri mubazi iri. Iri muBeijing, kambani iyi ine timu yakasimba yeR&D, yekugadzira nekutengesa, inotarisa pakuvandudza nekushandisa tekinoroji yekuongorora ropa neropa.
Nekusimba kwayo kukuru kwehunyanzvi, Succeeder yakahwina mapatenti makumi mana nemashanu ane mvumo, anosanganisira mapatenti gumi nemana ekugadzira zvinhu zvitsva, mapatenti gumi nematanhatu emhando dzekushandisa uye mapatenti gumi nemashanu ekugadzira.
Kambani iyi inewo zvitupa zvekunyoresa zvigadzirwa zvemhando yechitatu zvemhando yechitatu, zvitupa zvekuisa zvemhando yechitatu zvemhando yechitatu, uye chitupa cheEU CE chezvigadzirwa gumi nemana, uye yakapasa chitupa cheISO 13485 chehunhu hwekutarisira kuti chigadzirwa chive chakanakisa uye chakagadzikana.
Succeeder haisi kambani huru yeBeijing Biomedicine Industry Leapfrog Development Project (G20) chete, asi yakabudirirawo kupinda muScience and Technology Innovation Board muna 2020, ichibudirira zvikuru mukukura kwekambani iyi.
Parizvino, kambani iyi yakavaka network yekutengesa munyika yese inosanganisira mazana evamiririri nemahofisi.
Zvigadzirwa zvayo zvinotengeswa zvakanaka munzvimbo zhinji dzenyika.
Iri kuwedzerawo misika yekune dzimwe nyika uye iri kuramba ichivandudza kukwikwidza kwayo pasi rose.
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