KUDZIWA KWA KUGWIRITSA NTCHITO NTCHITO YOFUNIKA
NTCHITO YOPHUNZITSA MA REAGENT
Kuyang'anira bwino mankhwala a heparin ndi sayansi komanso luso, ndipo kumagwirizana mwachindunji ndi kupambana kapena kulephera kwa mankhwala oletsa magazi kuundana.
Mankhwala a Heparin amagwiritsidwa ntchito kwambiri popewa ndi kuchiza matenda a thromboembolic ndipo amagwiritsidwa ntchito kwambiri m'magawo ambiri azachipatala.
Komabe, momwe mungagwiritsire ntchito moyenera komanso moyenera mankhwalawa kuti muwonetsetse kuti chitetezo ndi kugwira ntchito bwino kwa chithandizo kwakhala cholinga cha madokotala nthawi zonse.
"Yotulutsidwa posachedwapa"Mgwirizano wa Akatswiri pa Kuyang'anira Mankhwala a Heparin m'chipatala"Anafotokoza mokwanira za zizindikiro, mlingo, kuyang'anira ndi zina zokhudzana ndi mankhwala a heparin, makamaka anafotokoza njira zogwiritsira ntchito kuchipatala zizindikiro za labotale monga ntchito ya anti-Xa."
Nkhaniyi ifotokoza mwachidule mfundo zazikulu za mgwirizanowu kuti zithandize ogwira ntchito zachipatala kuzigwiritsa ntchito bwino.
1-Kusankha zizindikiro zowunikira za labotale
Mgwirizanowu ukugogomezera kuti zinthu zomwe ziyenera kuyang'aniridwa musanagwiritse ntchito mankhwala a heparin komanso mukamamwa mankhwalawa zikuphatikizapo koma sizimangokhala pa hemodynamics, ntchito ya impso, hemoglobin, kuchuluka kwa ma platelet ndi magazi obisika m'chimbudzi.
Mfundo ziwiri zofunika pakuyang'anira mankhwala osiyanasiyana a heparin
(1) Heparin yosadulidwa (UFH)
Mlingo wochizira wa UFH uyenera kuyang'aniridwa ndipo mlingowo uyenera kusinthidwa malinga ndi ntchito ya anticoagulant.
Kuwunika kwa ACT kumagwiritsidwa ntchito pogwiritsira ntchito mlingo waukulu (monga nthawi ya PCI ndi kutuluka kwa magazi kunja kwa thupi [CPB]).
Muzochitika zina (monga chithandizo cha ACS kapena VTE), APTT yokonzedwa kuti igwiritsidwe ntchito polimbana ndi Xa kapena anti-Xa ingasankhidwe.
(2) Heparin yolemera pang'ono (LMWH)
Malinga ndi makhalidwe a mankhwala a LMWH, kuyang'anira nthawi zonse ntchito ya anti-Xa sikofunikira.
Komabe, odwala omwe ali ndi thupi lolemera kwambiri kapena lochepa, omwe ali ndi pakati, kapena omwe ali ndi vuto la impso ayenera kuyesedwa mosamala kapena kusintha mlingo kutengera ntchito ya anti-Xa.
(3) Kuwunika kwa Fondaparinux sodium
Odwala omwe amagwiritsa ntchito mankhwala oletsa kapena ochizira a fondaparinux sodium safunika kuyang'aniridwa pafupipafupi ndi ntchito ya anti-Xa, koma kuyang'aniridwa kwa ntchito ya anti-Xa kumalimbikitsidwa kwa odwala onenepa kwambiri omwe ali ndi vuto la impso.
3- Kukana kwa Heparin ndi chithandizo cha HIT
Ngati mukukayikira kuti pali vuto la antithrombin (AT) kapena heparin resistance, ndi bwino kuyesa kuchuluka kwa ntchito ya AT kuti muchotse kusowa kwa AT ndikuwongolera chithandizo cholowa m'malo chofunikira.
Ndikofunikira kugwiritsa ntchito njira yoyesera ya chromogenic substrate kutengera IIa (yomwe ili ndi thrombin ya bovine) kapena Xa pa ntchito ya AT.
Kwa odwala omwe akuganiziridwa kuti ali ndi heparin-induced thrombocytopenia (HIT), kuyezetsa ma antibody a HIT nthawi zambiri sikuvomerezeka kwa odwala omwe ali ndi UFH omwe ali ndi mwayi wochepa wa HIT (≤3 points) kutengera chigoli cha 4T.
Kwa odwala omwe ali ndi mwayi wapakati mpaka wapamwamba wa HIT (ma point 4-8), kuyezetsa ma antibodies a HIT kumalimbikitsidwa.
Kuyeza ma antibodies osiyanasiyana kumalimbikitsidwa kuti kukhale ndi mlingo wokwera, pomwe kuyesa ma antibodies enaake a IgG kumalimbikitsidwa kuti kukhale ndi mlingo wochepa.
4- Kuwongolera Kuopsa kwa Kutuluka Magazi ndi Chithandizo Chosintha
Ngati magazi atuluka kwambiri chifukwa cha heparin, mankhwala oletsa thrombosis ayenera kuthetsedwa nthawi yomweyo, ndipo kukhazikika kwa hemostasis ndi hemodynamic kuyenera kusungidwa mwachangu momwe zingathere.
Protamine imalimbikitsidwa ngati mankhwala oyamba ochepetsa heparin.
Mlingo wa protamine uyenera kuwerengedwa kutengera nthawi yomwe heparin imagwiritsidwa ntchito.
Ngakhale palibe njira zenizeni zowunikira protamine, kuwunika kwachipatala kwa zotsatira zobweza za protamine kungachitike poyang'ana momwe wodwalayo akutuluka magazi komanso kusintha kwa APTT.
Palibe mankhwala enieni a fondaparinux sodium; mphamvu zake zoletsa magazi kuundana zimatha kusinthidwa pogwiritsa ntchito FFP, PCC, rFVIIa, komanso kusinthana kwa plasma.
Kugwirizana kumeneku kumapereka ndondomeko zowunikira mwatsatanetsatane ndi mfundo zomwe tikufuna, zomwe zimatithandiza kupanga zisankho zolondola kwambiri pazochitika zachipatala.
Mankhwala oletsa magazi kutuluka magazi ndi lupanga lakuthwa konsekonse: kugwiritsa ntchito moyenera kungateteze ndikuchiza matenda a thrombosis, koma kugwiritsa ntchito molakwika kungawonjezere chiopsezo cha kutuluka magazi.
Tikukhulupirira kuti kutanthauzira mgwirizanowu kukuthandizani kukhala ogwira mtima kwambiri pa ntchito zachipatala ndikupereka chithandizo chotetezeka komanso chothandiza kwambiri cha anticoagulant kwa odwala anu.
Beijing Succeeder Technology Inc. (khodi ya stock: 688338) yakhala ikugwira ntchito yozama kwambiri pa matenda a magazi kuyambira pomwe idakhazikitsidwa mu 2003, ndipo yadzipereka kukhala mtsogoleri pankhaniyi. Likulu lake ku Beijing, kampaniyo ili ndi gulu lamphamvu la kafukufuku ndi chitukuko, kupanga ndi kugulitsa, lomwe likuyang'ana kwambiri pakupanga ndi kugwiritsa ntchito ukadaulo wozindikira matenda a magazi ndi magazi.
Ndi luso lake lapamwamba kwambiri, Succeeder yapambana ma patent ovomerezeka 45, kuphatikiza ma patent opanga zinthu 14, ma patent a utility model 16 ndi ma patent opanga mapangidwe 15.
Kampaniyo ilinso ndi ziphaso 32 zolembetsera zida zamankhwala za Class II, ziphaso zitatu zoperekera zikalata za Class I, ndi chiphaso cha EU CE cha zinthu 14, ndipo yapambana chiphaso cha ISO 13485 cha kayendetsedwe kabwino ka dongosolo kuti zitsimikizire kuti khalidwe la malonda ndi labwino komanso lokhazikika.
Succeeder si kampani yofunika kwambiri ya Beijing Biomedicine Industry Leapfrog Development Project (G20) yokha, komanso idalowa mu Science and Technology Innovation Board mu 2020, zomwe zidapangitsa kuti kampaniyo ikule bwino kwambiri.
Pakadali pano, kampaniyo yamanga netiweki yogulitsa mdziko lonse yomwe imakhudza othandizira ndi maofesi ambirimbiri.
Zogulitsa zake zimagulitsidwa bwino m'madera ambiri mdziko muno.
Ikukulitsanso misika yakunja ndikupitilizabe kupititsa patsogolo mpikisano wake wapadziko lonse lapansi.
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