E nwere usoro coagulation na anticoagulation n'ọbara mmadụ. N'ọnọdụ nkịtị, ha abụọ na-enwe nguzozi siri ike iji hụ na ọbara na-erugharị n'ime arịa ọbara, ha agaghịkwa emepụta thrombus. N'ihe gbasara obere ọbara mgbali elu, enweghị mmiri ọṅụṅụ, wdg, ọbara na-erugharị ga-adị nwayọ, ọbara ga-adị n'otu ma na-agbagharị agbagharị, ọrụ coagulation ga-adị oke ike ma ọ bụ ọrụ anticoagulation ga-ebelata, nke ga-emebi nguzozi a ma mee ka ndị mmadụ nọrọ n'ọnọdụ "thrombotic". Thrombosis nwere ike ime ebe ọ bụla n'ime arịa ọbara. Thrombus na-asọfe na ọbara dị n'ime arịa ọbara. Ọ bụrụ na ọ nọrọ n'ime akwara ụbụrụ ma gbochie ọbara nkịtị nke akwara ụbụrụ, ọ bụ thrombosis ụbụrụ, nke ga-akpata stroke ischemic. Arịa akwara obi nwere ike ibute infarction myocardial, na mgbakwunye, thrombosis akwara ala, thrombosis venous miri emi na nsọtụ ala, na pulmonary embolism.

N'ime ha, ọtụtụ n'ime ha ga-enwe nnukwu mgbaàmà na mbido mbụ, dị ka hemiplegia na aphasia n'ihi infarction ụbụrụ; nnukwu precordial colic na infarction myocardial; nnukwu mgbu obi, nkụchi obi, hemoptysis nke infarction pulmonary kpatara; Ọ nwere ike ibute ihe mgbu n'ụkwụ, ma ọ bụ mmetụta oyi na claudication n'oge na-adịghị anya. Obi dị oke njọ, infarction ụbụrụ na infarction pulmonary nwekwara ike ibute ọnwụ mberede. Mana mgbe ụfọdụ enweghị ihe mgbaàmà doro anya, dị ka thrombosis miri emi nke akwara dị n'akụkụ ala, naanị nwa ehi na-afụ ụfụ ma na-adịghị mma. Ọtụtụ ndị ọrịa chere na ọ bụ n'ihi ike ọgwụgwụ ma ọ bụ oyi, mana ha anaghị ewere ya nke ọma, yabụ ọ dị mfe ịhapụ oge kacha mma maka ọgwụgwọ. Ọ bụ ihe mwute karịsịa na ọtụtụ ndị dọkịta na-enwekarị nchọpụtahie. Mgbe edema obere akụkụ ahụ na-apụta, ọ bụghị naanị na ọ ga-eweta nsogbu na ọgwụgwọ ahụ, kamakwa ọ ga-ahapụkwa ya ngwa ngwa.