KEV KHO MOB TXOG KEV SIB THOV KOM TXHEEB XYUAS COV KAB MOB COAGULATION
DAIM NTAWV THOV ANALYZER REAGENTS
Kev saib xyuas cov tshuaj heparin kom zoo yog ib qho kev tshawb fawb thiab kev kos duab, thiab nws muaj feem cuam tshuam ncaj qha rau kev vam meej lossis kev ua tsis tiav ntawm kev kho mob anticoagulant.
Cov tshuaj Heparin feem ntau yog cov tshuaj anticoagulants rau kev tiv thaiv thiab kho cov kab mob thromboembolic thiab siv dav hauv ntau qhov chaw kho mob.
Txawm li cas los xij, yuav siv cov tshuaj no li cas thiab saib xyuas kom zoo kom ntseeg tau tias muaj kev nyab xeeb thiab ua tau zoo ntawm kev kho mob yeej ib txwm yog qhov tseem ceeb ntawm cov kws kho mob.
Cov ntawv tshaj tawm tsis ntev los no "Kev Pom Zoo Los Ntawm Cov Kws Tshaj Lij Txog Kev Saib Xyuas Kev Kho Mob ntawm Cov Tshuaj Heparin"tau tham txog tag nrho cov cim qhia, kev noj tshuaj, kev saib xyuas thiab lwm yam ntawm cov tshuaj heparin, tshwj xeeb tshaj yog piav qhia txog cov txheej txheem siv tshuaj ntawm cov ntsuas hauv chaw kuaj mob xws li kev ua haujlwm tiv thaiv Xa.
Tsab xov xwm no yuav sau cov ntsiab lus tseem ceeb ntawm qhov kev pom zoo no los pab cov neeg ua haujlwm hauv tsev kho mob siv nws zoo dua hauv kev xyaum.
1-Kev xaiv cov ntsuas kev soj ntsuam hauv chaw kuaj mob
Qhov kev pom zoo hais tias cov khoom dav dav uas yuav tsum tau saib xyuas ua ntej thiab thaum siv cov tshuaj heparin suav nrog tab sis tsis txwv rau hemodynamics, kev ua haujlwm ntawm lub raum, hemoglobin, platelet suav thiab cov ntshav occult hauv cov quav.
2-Cov ntsiab lus tseem ceeb rau kev saib xyuas cov tshuaj heparin sib txawv
(1) Cov tshuaj heparin tsis muaj feem cuam tshuam (UFH)
Yuav tsum tau saib xyuas cov koob tshuaj kho mob ntawm UFH thiab kho cov koob tshuaj raws li cov haujlwm anticoagulant.
Kev saib xyuas ACT yog siv rau kev siv tshuaj ntau (xws li thaum lub sijhawm PCI thiab kev ncig sab nraud [CPB]).
Hauv lwm qhov xwm txheej (xws li kev kho mob ACS lossis VTE), APTT kho rau anti-Xa lossis anti-Xa kev ua ub no tuaj yeem xaiv tau.
(2) Heparin hnyav molecular qis (LMWH)
Raws li cov yam ntxwv pharmacokinetic ntawm LMWH, kev saib xyuas tsis tu ncua ntawm kev ua haujlwm anti-Xa tsis tas yuav tsum muaj.
Txawm li cas los xij, cov neeg mob uas muaj qhov hnyav siab lossis qis, cev xeeb tub, lossis mob raum tsis zoo yuav tsum tau soj ntsuam kev nyab xeeb lossis hloov kho koob tshuaj raws li kev ua haujlwm anti-Xa.
(3) Kev soj ntsuam ntawm Fondaparinux sodium
Cov neeg mob uas siv cov tshuaj fondaparinux sodium los tiv thaiv lossis kho mob tsis tas yuav tsum tau saib xyuas kev ua haujlwm anti-Xa, tab sis kev saib xyuas kev ua haujlwm anti-Xa yog qhov pom zoo rau cov neeg rog rog uas tsis muaj zog raum.
3- Kev tiv thaiv Heparin thiab kev kho mob HIT
Thaum xav tias muaj qhov tsis txaus antithrombin (AT) lossis tsis kam heparin, nws raug nquahu kom kuaj cov qib AT ua haujlwm kom tsis txhob muaj qhov tsis txaus AT thiab coj kev kho mob hloov pauv tsim nyog.
Nws raug pom zoo kom siv cov chromogenic substrate assay raws li IIa (muaj bovine thrombin) lossis Xa rau AT kev ua ub no.
Rau cov neeg mob uas xav tias muaj mob ntshav qis heparin (HIT), feem ntau tsis pom zoo kom kuaj HIT antibody rau cov neeg mob uas raug UFH uas muaj feem yuav HIT tsawg (≤3 cov ntsiab lus) raws li qhov qhab nia 4T.
Rau cov neeg mob uas muaj feem yuav muaj HIT nruab nrab mus rau siab (4-8 cov ntsiab lus), kev kuaj HIT antibody yog qhov pom zoo.
Pom zoo kom muaj qhov ntsuas siab dua rau kev kuaj cov tshuaj tiv thaiv kab mob sib xyaw, thaum qhov ntsuas qis dua yog pom zoo rau kev kuaj cov tshuaj tiv thaiv kab mob IgG tshwj xeeb.
4- Kev Tswj Xyuas Kev Pheej Hmoo Los Ntshav thiab Kev Kho Mob Rov Qab
Yog tias muaj kev los ntshav hnyav uas cuam tshuam nrog heparin, cov tshuaj antithrombotic yuav tsum tsis txhob siv tam sim ntawd, thiab hemostasis thiab hemodynamic stability yuav tsum tau tswj kom sai li sai tau.
Protamine raug pom zoo kom siv ua thawj txoj kev kho mob rau kev tshem tawm cov tshuaj heparin.
Yuav tsum xam cov tshuaj protamine raws li lub sijhawm siv heparin.
Txawm hais tias tsis muaj cov txheej txheem saib xyuas tshwj xeeb rau protamine, kev soj ntsuam kev kho mob ntawm qhov cuam tshuam rov qab ntawm protamine tuaj yeem ua tau los ntawm kev saib xyuas tus neeg mob qhov xwm txheej los ntshav thiab kev hloov pauv hauv APTT.
Tsis muaj tshuaj tshwj xeeb rau fondaparinux sodium; nws cov teebmeem anticoagulant tuaj yeem thim rov qab siv FFP, PCC, rFVIIa, thiab txawm tias plasma pauv.
Qhov kev pom zoo no muab cov txheej txheem saib xyuas kom ntxaws thiab cov nqi tseem ceeb, pab peb txiav txim siab kom meej dua hauv kev kho mob.
Kev kho mob Anticoagulant yog rab ntaj ob sab: kev siv kom raug tuaj yeem tiv thaiv thiab kho cov kab mob thrombotic, tab sis kev siv tsis raug tuaj yeem ua rau muaj kev pheej hmoo ntawm kev los ntshav.
Peb vam tias kev txhais cov lus pom zoo no yuav pab koj ua haujlwm tau zoo dua hauv kev kho mob thiab muab kev kho mob anticoagulant uas muaj kev nyab xeeb dua thiab zoo dua rau koj cov neeg mob.
Beijing Succeeder Technology Inc. (tus lej khoom lag luam: 688338) tau koom nrog tob hauv kev kuaj mob coagulation txij li thaum nws tau tsim tsa xyoo 2003, thiab tau cog lus tias yuav ua tus thawj coj hauv daim teb no. Lub tuam txhab muaj lub hauv paus nyob hauv Beijing, muaj pab pawg R&D, kev tsim khoom thiab kev muag khoom zoo, tsom mus rau kev tsim kho tshiab thiab kev siv cov thev naus laus zis kuaj mob thrombosis thiab hemostasis.
Nrog nws lub zog zoo tshaj plaws, Succeeder tau yeej 45 daim ntawv pov thawj tso cai, suav nrog 14 daim ntawv pov thawj tsim khoom, 16 daim ntawv pov thawj qauv siv hluav taws xob thiab 15 daim ntawv pov thawj tsim qauv.
Lub tuam txhab kuj muaj 32 daim ntawv pov thawj rau npe khoom siv kho mob Class II, 3 daim ntawv pov thawj Class I, thiab daim ntawv pov thawj EU CE rau 14 yam khoom, thiab tau dhau daim ntawv pov thawj ISO 13485 kev tswj hwm zoo kom ntseeg tau tias qhov zoo tshaj plaws thiab ruaj khov ntawm cov khoom zoo.
Succeeder tsis yog tsuas yog ib lub tuam txhab tseem ceeb ntawm Beijing Biomedicine Industry Leapfrog Development Project (G20), tab sis kuj tau tsaws rau ntawm Science thiab Technology Innovation Board hauv xyoo 2020, ua tiav kev loj hlob ntawm lub tuam txhab.
Tam sim no, lub tuam txhab tau tsim ib lub network muag khoom thoob plaws lub tebchaws uas suav nrog ntau pua tus neeg sawv cev thiab chaw ua haujlwm.
Nws cov khoom muag tau zoo hauv feem ntau ntawm lub tebchaws.
Nws kuj tseem niaj hnub nthuav dav cov lag luam txawv teb chaws thiab txhim kho nws txoj kev sib tw thoob ntiaj teb tas li.
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